Junctional epidermolysis bullosa

Veterinary advice should be sought before applying any treatment or vaccine.

Junctional Epidermolysis Bullosa

Red Foot Disease, Hairless Foal Syndrome

Junctional epidermolysis bullosa (JEB) is an inherited disorder affecting foals of Belgium Draft Horses, American Saddlebreds and their relatives. The condition is caused by a mutation that inhibits the body's ability to produce certain proteins responsible for holding the skin onto the body. The foal starts to lose their hoof wall which often causes detachment of the hoof from its body. Oral ulcers may also appear. As the condition worsens, the foal will suffer increasing pain and discomfort and severe infections from the lesions.


Lesions all over body
Oral ulcers
Separation of the coronary bands from the hoof wall


  • History
  • Clinical signs
  • Physical exam
  • Skin biopsy
  • Genetic testing



There is no treatment. Foal should be euthanized.




Scientific Research

General Overviews

Age Range

Clinical signs begin to appear four to five days after birth, at which the foal develops lesions all over its body.

Commonly Affected Breeds

Saddlebred icon