Equine pegivirus (EPgV) is a newly discovered virus of the Flaviviridae family and Pegivirus Genus. It affects horses as well as humans and other animals. Human Pegivirus (HPgV)is a lymphotropic RNA-virus which infects approximately 5% of the world's human population. EPgV is thought to cause hepatic disease in horses. An outbreak involving 114 horses recently occurred in Pará State, located in northern Brazil.